Use Ad Units, not Ad Links

When creating your ad in the adsense setup, make you select Ad Units and not Ad Links.

Use one format size - 336 x 280 pixels:

The one format that worked well for the majority is the Large Rectangle (336X280). This same format have the tendency to result in higher CTR, or the click-through rates. Why choose this format out of the many you can use? Basically because the ads will look like normal web links, and people, being used to clicking on them, click these types of links. They may or may not know they are clicking on your Adsense but as long as there are clicks, then it will all be for your advantage.

Use custom color and fonts to match your site:

Choose a color that will go well with the background of your site. If your site has a white background, try to use white as the color of your ad border and background. The thought to patterning the colors is to make the Adsense look like it is part of the web pages. Again, This will result to more clicks from people visiting your site.

Choose the best performing position for your ad:

The left skyscraper is one of the most profitable Adsense placement areas at the moment. Researches have concluded that because of the way our eyes read content from left to right we can encourage ad clicks from left hand skyscrapers. A skyscraper that is also blended in with a couple of links with the majority of links being on the right of the screen works very well.  Rating 7/10

The left small ad position is also a profitable position but lacks the punch of the skyscraper because only a few ads are shown. This causes less ad rotation and restricts the Google algorithm in deciding which ads are most profitable for your site. When blended with a small number of site links you can increase CTR by attracting more users without plaguing them with too many ads like the skyscraper.  Rating 6/10

The middle top is a decent enough earner where as it seems as though it should be the best. If you can blend the ad into site headings and navigation links then the middle top can become a good Adsense earner. However, this is a difficult process and its much easier to use the 'middle content' ad position.  Rating 8 / 10

The middle content position is the well known highest payer, simply because its wrapped into site content and attracts the users eye. We recommend using the add in an html table to align the ad with the central content of your page.  The trick is to hide the ads as much as possible.  Rating 10/10

Surprise earner

The middle footer is the undiscovered earner that most people often miss. If you think about it logically the bottom of the content presents the point at which a user has finished reading the content and is open to click on an ad. If your ads are all positioned at the top of the page then the user will most likely close the screen instead. Use this position together with internal navigation links for the best affect on Adsense earnings. Rating 9/10

Generally the right side of the screen has lower ratings, around 3-5.